Analysts’ Weekly Ratings Updates for Axsome Therapeutics (AXSM)

Several brokerages have updated their recommendations and price targets on shares of Axsome Therapeutics (NASDAQ: AXSM) in the last few weeks:

  • 10/14/2026 – Axsome Therapeutics had its “outperform” rating reaffirmed by Royal Bank Of Canada.
  • 10/8/2026 – Axsome Therapeutics had its price target lowered by Royal Bank Of Canada from $297.00 to $295.00. They now have an “outperform” rating on the stock.
  • 9/29/2026 – Axsome Therapeutics had its price target lowered by Deutsche Bank Aktiengesellschaft from $280.00 to $267.00. They now have a “buy” rating on the stock.
  • 9/25/2026 – Axsome Therapeutics had its price target lowered by Morgan Stanley from $251.00 to $247.00. They now have an “equal weight” rating on the stock.
  • 9/25/2026 – Axsome Therapeutics had its “buy” rating reaffirmed by HC Wainwright.
  • 9/23/2026 – Axsome Therapeutics had its price target raised by Truist Financial Corporation from $200.00 to $285.00. They now have a “buy” rating on the stock.
  • 9/18/2026 – Axsome Therapeutics had its “overweight” rating reaffirmed by Piper Sandler. They now have a $258.00 price target on the stock.
  • 8/31/2026 – Axsome Therapeutics had its “buy” rating reaffirmed by HC Wainwright. They now have a $290.00 price target on the stock.
  • 8/24/2026 – Axsome Therapeutics had its “buy” rating reaffirmed by HC Wainwright.
  • 8/24/2026 – Axsome Therapeutics had its “buy” rating reaffirmed by UBS Group AG.
  • 8/18/2026 – Axsome Therapeutics was upgraded by Zacks Research from “strong sell” to “hold”.

Insider Buying and Selling at Axsome Therapeutics

In related news, COO Mark L. Jacobson sold 10,000 shares of the firm’s stock in a transaction that occurred on Thursday, September 3rd. The stock was sold at an average price of $208.65, for a total value of $2,086,500.00. Following the sale, the chief operating officer directly owned 10,000 shares in the company, valued at $2,086,500. This trade represents a 50.00% decrease in their position. The transaction was disclosed in a legal filing with the Securities & Exchange Commission, which is available through this hyperlink. Also, CEO Herriot Tabuteau sold 45,004 shares of the firm’s stock in a transaction on Wednesday, August 5th. The shares were sold at an average price of $212.01, for a total value of $9,541,298.04. Following the transaction, the chief executive officer directly owned 7,229 shares in the company, valued at $1,532,620.29. This trade represents a 86.16% decrease in their ownership of the stock. The disclosure for this sale is available in the SEC filing. In the last three months, insiders have sold 59,664 shares of company stock valued at $12,624,805. Corporate insiders own 20.60% of the company’s stock.

Axsome Therapeutics, Inc is a commercial-stage biopharmaceutical company focused on developing and commercializing therapies for central nervous system (CNS) disorders. The company uses differentiated product candidates and targeted mechanisms to address conditions with significant unmet medical needs, including depression, sleep disorders, migraine, and other neurological or psychiatric diseases.

Axsome’s lead commercial product is Auvelity (dextromethorphan hydrobromide and bupropion hydrochloride), an oral medicine approved in the United States for the treatment of major depressive disorder in adults.

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