4,211,659 Shares in Septerna, Inc. $SEPN Acquired by Trv Gp Vi LLC

Posted by Geri Gentry on Aug 19th, 2026

Trv Gp Vi LLC bought a new position in shares of Septerna, Inc. (NASDAQ:SEPN – Free Report) during the second quarter, according to the company in its most recent 13F filing with the Securities and Exchange Commission. The firm bought 4,211,659 shares of the company’s stock, valued at approximately $141,048,460,000. Septerna accounts for 60.7% of Trv Gp Vi LLC’s portfolio, making the stock its largest holding. Trv Gp Vi LLC owned 9.34% of Septerna at the end of the most recent quarter.

Several other large investors have also added to or reduced their stakes in SEPN. Goldman Sachs Group Inc. boosted its position in shares of Septerna by 86.6% in the fourth quarter. Goldman Sachs Group Inc. now owns 2,715,129 shares of the company’s stock worth $75,698,000 after purchasing an additional 1,260,409 shares during the period. BlackRock Inc. bought a new stake in shares of Septerna during the 2nd quarter valued at $64,706,000. Vanguard Group Inc. raised its position in shares of Septerna by 7.4% during the 3rd quarter. Vanguard Group Inc. now owns 1,518,757 shares of the company’s stock valued at $28,568,000 after purchasing an additional 104,394 shares during the period. ADAR1 Capital Management LLC raised its position in shares of Septerna by 38.9% during the 3rd quarter. ADAR1 Capital Management LLC now owns 1,176,491 shares of the company’s stock valued at $22,130,000 after purchasing an additional 329,264 shares during the period. Finally, Janus Henderson Group PLC purchased a new position in shares of Septerna during the 1st quarter valued at $21,334,000.

Wall Street Analysts Forecast Growth

SEPN has been the subject of a number of analyst reports. Stifel Nicolaus set a $49.00 price target on Septerna in a research note on Tuesday, August 11th. JonesTrading boosted their price objective on Septerna from $43.00 to $62.00 and gave the company a “buy” rating in a research report on Thursday, August 13th. HC Wainwright upped their price objective on Septerna from $40.00 to $60.00 and gave the stock a “buy” rating in a research note on Wednesday, August 12th. Wells Fargo & Company increased their target price on Septerna from $48.00 to $50.00 and gave the stock an “overweight” rating in a research report on Wednesday, August 12th. Finally, Weiss Ratings reissued a “sell (d-)” rating on shares of Septerna in a research note on Friday, July 17th. One analyst has rated the stock with a Strong Buy rating, eight have issued a Buy rating, one has issued a Hold rating and one has assigned a Sell rating to the company. Based on data from MarketBeat, the company has an average rating of “Moderate Buy” and an average price target of $51.33.

Check Out Our Latest Stock Analysis on SEPN

Insider Buying and Selling at Septerna

In other news, COO Elizabeth Bhatt sold 25,000 shares of Septerna stock in a transaction dated Tuesday, August 11th. The stock was sold at an average price of $44.00, for a total value of $1,100,000.00. Following the sale, the chief operating officer directly owned 174,209 shares of the company’s stock, valued at approximately $7,665,196. The trade was a 12.55% decrease in their ownership of the stock. The sale was disclosed in a document filed with the SEC, which can be accessed through this hyperlink. Also, insider Samira Shaikhly sold 11,798 shares of the stock in a transaction that occurred on Tuesday, May 26th. The shares were sold at an average price of $30.06, for a total value of $354,647.88. Following the transaction, the insider directly owned 793 shares of the company’s stock, valued at approximately $23,837.58. The trade was a 93.70% decrease in their ownership of the stock. The disclosure for this sale is available in the SEC filing. Insiders sold 72,828 shares of company stock valued at $2,684,314 in the last 90 days. Insiders own 5.80% of the company’s stock.

Septerna Stock Performance

SEPN stock opened at $43.80 on Wednesday. The company’s fifty day moving average price is $36.37 and its 200-day moving average price is $29.94. Septerna, Inc. has a one year low of $10.74 and a one year high of $51.10. The company has a market capitalization of $2.04 billion, a PE ratio of -81.11 and a beta of 2.29.

Septerna (NASDAQ:SEPN – Get Free Report) last posted its earnings results on Monday, August 10th. The company reported ($0.29) earnings per share for the quarter, beating the consensus estimate of ($0.43) by $0.14. The company had revenue of $26.75 million during the quarter, compared to analysts’ expectations of $19.22 million. Septerna had a negative net margin of 24.51% and a negative return on equity of 9.57%. On average, research analysts predict that Septerna, Inc. will post -1.36 EPS for the current fiscal year.

Septerna Profile

(Free Report)

We are a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) oral small molecule drug discovery powered by our proprietary Native Complex Platform™. Our industrial-scale platform aims to unlock the full potential of GPCR therapies and has led to the discovery and development of our deep pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. GPCRs are the largest and most diverse family of cell membrane receptors and regulate physiological processes in nearly every organ system of the human body.