Carisma Therapeutics (NASDAQ:CARM – Get Free Report) and Cassava Sciences (NASDAQ:SAVA – Get Free Report) are both small-cap medical companies, but which is the superior investment? We will compare the two businesses based on the strength of their profitability, risk, institutional ownership, earnings, dividends, analyst recommendations and valuation.
Earnings and Valuation
This table compares Carisma Therapeutics and Cassava Sciences”s revenue, earnings per share and valuation.
| Gross Revenue | Price/Sales Ratio | Net Income | Earnings Per Share | Price/Earnings Ratio | |
| Carisma Therapeutics | $10.77 million | 0.19 | -$60.48 million | ($0.80) | -0.06 |
| Cassava Sciences | N/A | N/A | -$24.34 million | ($2.55) | -1.16 |
Profitability
This table compares Carisma Therapeutics and Cassava Sciences’ net margins, return on equity and return on assets.
| Net Margins | Return on Equity | Return on Assets | |
| Carisma Therapeutics | -254.28% | N/A | -192.17% |
| Cassava Sciences | N/A | -66.16% | -53.11% |
Institutional and Insider Ownership
44.3% of Carisma Therapeutics shares are owned by institutional investors. Comparatively, 38.0% of Cassava Sciences shares are owned by institutional investors. 6.9% of Carisma Therapeutics shares are owned by insiders. Comparatively, 2.4% of Cassava Sciences shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a stock is poised for long-term growth.
Analyst Ratings
This is a summary of current recommendations and price targets for Carisma Therapeutics and Cassava Sciences, as reported by MarketBeat.com.
| Sell Ratings | Hold Ratings | Buy Ratings | Strong Buy Ratings | Rating Score | |
| Carisma Therapeutics | 1 | 4 | 1 | 1 | 2.29 |
| Cassava Sciences | 1 | 1 | 0 | 0 | 1.50 |
Carisma Therapeutics currently has a consensus target price of $1.93, suggesting a potential upside of 3,796.76%. Cassava Sciences has a consensus target price of $2.00, suggesting a potential downside of 32.43%. Given Carisma Therapeutics’ stronger consensus rating and higher possible upside, research analysts clearly believe Carisma Therapeutics is more favorable than Cassava Sciences.
Risk and Volatility
Carisma Therapeutics has a beta of 1.94, meaning that its share price is 94% more volatile than the S&P 500. Comparatively, Cassava Sciences has a beta of -1.1, meaning that its share price is 210% less volatile than the S&P 500.
Summary
Carisma Therapeutics beats Cassava Sciences on 11 of the 14 factors compared between the two stocks.
About Carisma Therapeutics
Carisma Therapeutics, Inc., a clinical-stage cell therapy company, focuses on discovering and developing immunotherapies to treat cancer and other serious diseases in the United States. The company's ex vivo CAR-M cell therapies include CT-0508, a CAR-macrophage, which is in Phase 1 clinical trial to treat solid tumors; CT-0525, a CAR-monocyte that is in Phase 1 clinical trial to treat solid tumors; and CT-1119, a mesothelin-targeted CAR-Monocyte that is in pre-clinical stage to treat patients with advanced mesothelin-positive solid tumors, including lung cancer, mesothelioma, pancreatic cancer, ovarian cancer, and others. It is also developing in vivo CAR-M cell therapies in collaboration with Moderna Therapeutics to address multiple cancer targets; and multiple assets for the potential treatment of diseases beyond oncology, including fibrosis and other immunologic and inflammatory diseases. The company was formerly known as CARMA Therapeutics Inc. and changed its name to Carisma Therapeutics, Inc. in May 2017. The company was founded in 2016 and is headquartered in Philadelphia, Pennsylvania.
About Cassava Sciences
Cassava Sciences, Inc., a clinical stage biotechnology company, develops drugs for neurodegenerative diseases. Its lead therapeutic product candidate is simufilam, a small molecule drug, which is completed Phase 2 clinical trial; and investigational diagnostic product candidate is SavaDx, a blood-based biomarker/diagnostic to detect Alzheimer's disease. The company was formerly known as Pain Therapeutics, Inc. and changed its name to Cassava Sciences, Inc. in March 2019. Cassava Sciences, Inc. was incorporated in 1998 and is based in Austin, Texas.
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