Cytosorbents (NASDAQ:CTSO) versus Orthofix Medical (NASDAQ:OFIX) Head to Head Review

Cytosorbents (NASDAQ:CTSO) and Orthofix Medical (NASDAQ:OFIX) are both small-cap medical companies, but which is the better business? We will contrast the two businesses based on the strength of their institutional ownership, risk, analyst recommendations, dividends, valuation, earnings and profitability.

Analyst Ratings

This is a summary of current ratings and price targets for Cytosorbents and Orthofix Medical, as provided by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Cytosorbents 0 0 3 0 3.00
Orthofix Medical 0 1 1 0 2.50

Cytosorbents presently has a consensus target price of $13.67, suggesting a potential upside of 185.91%. Orthofix Medical has a consensus target price of $60.00, suggesting a potential upside of 13.44%. Given Cytosorbents’ stronger consensus rating and higher probable upside, research analysts clearly believe Cytosorbents is more favorable than Orthofix Medical.

Risk and Volatility

Cytosorbents has a beta of 1.7, suggesting that its share price is 70% more volatile than the S&P 500. Comparatively, Orthofix Medical has a beta of 0.41, suggesting that its share price is 59% less volatile than the S&P 500.


This table compares Cytosorbents and Orthofix Medical’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Cytosorbents -72.43% -105.97% -53.26%
Orthofix Medical 1.75% 9.50% 6.81%

Earnings & Valuation

This table compares Cytosorbents and Orthofix Medical’s revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Cytosorbents $22.50 million 6.86 -$17.21 million ($0.56) -8.54
Orthofix Medical $453.04 million 2.23 $13.81 million $1.96 26.98

Orthofix Medical has higher revenue and earnings than Cytosorbents. Cytosorbents is trading at a lower price-to-earnings ratio than Orthofix Medical, indicating that it is currently the more affordable of the two stocks.

Institutional & Insider Ownership

26.3% of Cytosorbents shares are owned by institutional investors. Comparatively, 95.1% of Orthofix Medical shares are owned by institutional investors. 5.6% of Cytosorbents shares are owned by company insiders. Comparatively, 5.8% of Orthofix Medical shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.


Orthofix Medical beats Cytosorbents on 9 of the 14 factors compared between the two stocks.

About Cytosorbents

Cytosorbents Corporation, a critical care focused immunotherapy company, engages in the research, development, and commercialization of medical devices with its blood purification technology platform incorporating a proprietary adsorbent and porous polymer technology worldwide. The company's flagship product is CytoSorb device, an extracorporeal cytokine filter designed for the adjunctive therapy in the treatment of sepsis; adjunctive therapy in other critical care applications; prevention and treatment of post-operative complications of cardiopulmonary bypass surgery; and prevention and treatment of organ dysfunction in brain-dead organ donors to increase the number and quality of viable organs harvested from donors. It also provides VetResQ device for adjunctive therapy in the treatment of sepsis, pancreatitis, and other critical illnesses in animals. In addition, the company develops CytoSorb-XL device for adjunctive therapy in the treatment of sepsis and other critical illnesses; HemoDefend blood purification technology platform to reduce contaminants in the blood supply that can cause transfusion reactions or disease when administering blood and blood products to patients; K+ontrol, a development stage blood purification technology; and ContrastSorb for the removal of IV contrast in blood administered during CT imaging, an angiogram, or during a vascular interventional radiology procedure to reduce the risk of contrast-induced nephropathy. Further, it is involved in the development of BetaSorb device for the prevention and treatment of health complications caused by the accumulation of metabolic toxins in patients with chronic renal failure; and DrugSorb, an extracorporeal hemoperfusion cartridge designed to remove toxic chemicals from the blood. The company was formerly known as MedaSorb Technologies Corporation and changed its name to CytoSorbents Corporation in May 2010. The company was founded in 1997 and is based in Monmouth Junction, New Jersey.

About Orthofix Medical

Orthofix Medical Inc., a medical device company, provides musculoskeletal healing products and therapies worldwide. It operates through four segments: Bone Growth Therapies, Spinal Implants, Biologics, and Orthofix Extremities. The Bone Growth Therapies segment manufactures, distributes, and provides support services for bone growth stimulator devices that enhance bone fusion and are indicated as treatment to enhance fusion success rates in cervical and lumbar spine, as well as a therapeutic treatment for non-spinal appendicular fractures. The Spinal Implants segment designs, develops, and markets a portfolio of implant products used in surgical procedures of the spine. The Biologics segment provides a portfolio of regenerative products and tissue forms that allow physicians to treat a range of spinal and orthopedic conditions. The Orthofix Extremities segment designs, develops, and markets orthopedic products used in fracture repair, deformity correction, and bone reconstruction procedures. The company markets and distributes its products through direct sales representatives; independent distributors; and employed and independent sales representatives to physicians, hospitals, ambulatory surgery centers, integrated health delivery systems, and other purchasing organizations. The company was formerly known as Orthofix International N.V. and changed its name to Orthofix Medical Inc. in July 2018. Orthofix Medical Inc. was founded in 1987 and is headquartered in Lewisville, Texas.

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